[Possible hypoglycemic effect of aloe vera L. high molecular weight fractions on type 2 diabetic patients]

Aloe vera L. high molecular weight fractions [AHM] containing less than 10 ppm of barbaloin and polysaccharide [MW: 1.000KD] with glycoprotein, verectin [MW 29KD], were prepared by patented hyper-dry system in combination of freeze-dry technique with micro wave and far infrared radiation. AHM produced significant decrease in blood glucose level sustained for 6 weeks of the start of the study. Significant decrease in triglycerides was only observed 4 weeks after treatment and continued thereafter. No deterious effects on kidney and liver functions were apparent. Treatment of diabetic patients with AHM may relief vascular complications probably via activation of immunosystem

Three basic patterns of changes in serum thyroid hormone levels in graves' disease during the one-year period after radioiodine therapy

Was to clarify the characteristic patterns of the thyroid hormonal changes in Graves' disease during the one-year period after [131]I therapy considering that few serial hormonal data during this period are available in the literature. The levels of serum T[3], T[4] and FT[4] before and during one year were plotted as a function of time in 86 therapy courses of 70 patients without subsequent antithyroid or steroid therapy. 35 euthyroid, 6 hypothyroid and 29 hyperthyroid states were obtained during one year after therapy. Although individual patients had individual hormonal changing patterns, 3 common basic patterns were observed from baseline to one month [early] and thereafter [late], respectively. The early patterns were a decrease in 54 [77%], a minimum change in 8 [11.5%] and an increase in 8 [11.5%]. The late patterns were a stable state after an initial decrease with a bottom followed by an increase [valley pattern] in 47 [67%], a stable state after an initial increase with a peak followed by a decrease with a bottom and a subsequent re-increase [mountain pattern] in 12 [17%] and a late stable state after a gradual slow decrease without an obvious bottom near or till one year [downhill pattern] in 11 [16%]. The bottom level and the degree of hormonal recovery from the bottom determined the stable euthyroid, hypothyroid or hyperthyroid state in 49 [86%] of 59 with the valley or mountain pattern. Most of the bottom levels [81%] and transient abnormal changes including transient hypothyroidism [93%, 13/14], peak or hyperthyroidism [85%, 11/13] and euthyroidism [67%, 10/15] appeared within 6 months. The posttherapeutic stable euthyroid, hypothyroid or hyperthyroid state could be judged from the hormonal patterns in 57% [39/68] from 2.5 to 6 months, in 18% [12/68] from 6 to 9 months and in 25% [17/68] thereafter. Although the changes in thyroid hormones are not constant in Graves' disease during one year after [131]I therapy, there are three basic patterns; valley, mountain and downhill patterns from one month after therapy. The post-therapeutic stable state can be judged by the hormonal level recovered from the bottom in most patients